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KMID : 1134820090380010019
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 1 p.19 ~ p.24
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Antioxidative and Antimutagenic Effects of Agaricus bisporus Ethanol Extracts
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Yun Mi-Ja
Oh Se-In
Lee Mee-Sook
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Abstract
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This study was performed to investigate the antioxidative effects such as the inhibition of malondialdehyde
(MDA) and bovine serum albumin (BSA) conjugation reaction, inhibition of Fe2+-induced lipid peroxidation and the scavenging effect on 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical, as well as antimutagenic capacities as Ames test in ethanol extracts of Agaricus bisporus. Agaricus bisporus ethanol extracts inhibited Fe2+-induced lipid peroxidation and scavenged DPPH radical. The IC50 of Agaricus bisporus ethanol extracts were 78.63 mg/assay for inhibition of MDA with BSA conjugation reaction, 4.06 mg/ assay for inhibition of Fe2+-induced lipid peroxidation and 1.08 mg/assay for scavenging effect on DPPH radical. So, among the methods used in this study, the most effective antioxidative capacity in ethanol extracts of Agaricus bisporus was the scavenging effect on DPPH radical. The indirect and direct antimutagenic effects of ethanol extracts of Agaricus bisporus were examined by Ames test using Salmonella Typhimurium TA98 and TA100. The inhibitory effects on direct mutagenicity mediated by sodium azide in Salmonella Typhimurium TA100 and 2-nitrofluorene in Salmonella Typhimurium TA98 were 100%. The inhibition rates on indirect mutagenicity mediated by 2-anthramine were 86.09% in the Salmonella Typhimurium TA98 and 81.93% in the Salmonella Typhimurium TA100.
The ethanol extracts of Agaricus bisporus showed considerable antioxidative activity and strong antimutagenic capacity.
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KEYWORD
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MDA & BSA conjugation reaction, lipid peroxidation, DPPH radical scavenging effect, Ames test,
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